SSRIs and Psilocybin: How They Interact

This guide explores how SSRIs interact with psilocybin—why these compounds may blunt or alter each other’s effects, what the science currently shows, and what to consider before tapering. You’ll find practical insights on serotonin receptor dynamics, examples of diminished psychedelic response, and key reasons to avoid DIY transitions. Whether you're considering microdosing or therapeutic journeys, this guide offers a clear foundation for safer, more informed decisions if you're prescribed SSRIs

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